Ms. Aloum, a pharmacy graduate and licensed pharmacist, proceeded with her master's degree in experimental pharmacology and therapeutics at University College London. She worked as a clinical instructor at the University of Sharjah and currently working as a senior lecturer in the Department of Medical Sciences at the College of Medicine and Health Sciences (CMHS). Ms. Aloum served as the director of the MDBS 606 Pharmacology and Therapeutics course and Co-director of the MDBS 705 Gastrointestinal course. She is currently teaching general biology courses to students across various fields.
Ms. Aloum has always been very passionate about teaching and she is dedicated to finding innovative ways to deliver information to students. Ms. Aloum received the Khalifa University Faculty Teaching Excellence award for the academic year 2019-2020 to acknowledge her innovative teaching skills and passion for teaching. She has diverse experience in molecular pharmacology, biochemical, pharmacy practice, and drug discovery and development research. Ms. Aloum won several regional research awards such as the Think Science competition and the Sharjah Science Festival.
Brain penetration of Pralidoxime (PAM) vs Nano Encapsulated Pralidoxime (Nano-PAM)
Organophosphorus (OP) compounds are used as either pesticides, medication, or chemical warfare nerve agents, the exposure to the former is responsible for the majority of OP compound toxicity. OP toxicity arises from the irreversible inhibition of acetylcholinesterase (AChE). OP compounds can easily cross the blood-brain barrier (BBB) due to their small size and lipophilic nature. The core treatment for OP poisoning involves oximes which reactivate phosphylated AChE. One of the main drawbacks of oxime therapy is that it possesses a limited ability to reactivate AChE in the central nervous. Few studies investigated the potential of encapsulation of PAM to improve its ability to cross the BBB. The objective of this study is to compare the ability of nano-encapsulated PAM (Nano-PAM) in crossing the BBB compared to PAM by quantifying their levels in brain tissue at different time points.
Mixed Reality in Medical Education - The Future
