Separating molecules dissolved in organic solvents is important in pharmaceutical processing where separations can account for 70% of the total manufacturing cost. Membranes, and in particular nanofiltration, have been recognized as sustainable technologies allowing molecular sieving under mild conditions. Recent developments in solvent-resistance nanofiltration resulted in high performance materials. The latest generation of membranes are robust, and they operate under harsh conditions including extreme pH and polar aprotic solvents. The membranes have excellent selectivity, low molecular weight cut-off with reasonable throughput. These novel membranes enable new opportunities for various applications such as solvent, reagent and catalyst recovery. Hybrid processes consisting of continuous-flow reactors and membrane separation units are on the rise. In situ solvent recovery coupled to continuous adsorption processes for the isolation of bioactive plant-derived compounds also demonstrated significant improvement in process sustainability. The process development considerations for in situ solvent recovery with membranes will be discussed during the presentation.