Cardiomyocyte membranes (Sarcolemma and sarcoplasmic reticulum) are essential for maintaining proper excitation-contraction (E-C) coupling but are profoundly altered in diabetic cardiomyopathy, thus leading to impaired calcium signaling which detrimentally steers the heart into hypertrophic cardiomyopathy and failure. Mounting evidence implicates striatin (STRN) in cardiac function owing to its interaction with regulators of the L‐type calcium …
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