Dr. Shabir Hassan
Dr. Shabir Hassan Assistant Professor Biology

Contact Information
shabir.hassan@ku.ac.ae +971 2 312 5408

Biography

Dr. Shabir Hassan is an Assistant Professor of Biology. Before joining Khalifa, he was an Early Career Investigator at Harvard Medical School and Associate Bioengineer at Brigham and Women’s Hospital, USA.  In the last 5 years, his main focus of research has been devising in vitro platforms of diseases such as cancer and different tissues for drug discovery and drug delivery applications. Additionally, his interest revolves around 3D bioprinting of disease models to study genetic and rare diseases. He has an immense interest in bioimaging platforms such as mini-optical tomographic systems for studying 3D in vitro lab models.

During his PhD, he developed novel nano- and micro-materials conjugated with proteins to study their folding and aggregation kinetics, and their photothermal effects for cancer therapy.

He has won many awards for his academic and research excellence. Some notable ones include Certificate of Merit for academic excellence from University of Kashmir, Department of Biotechnology Fellowship from the Government of India, Endeavour Award from the Australian Government, two consecutive awards in Early and Advanced Mobility grant categories from the Swiss National Science Foundation for his scientific endeavors at Brigham and Women’s Hospital of Harvard Medical School, and the University of Twente, Netherlands, as a collaborating Institution. In 2019, he was awarded Excellence in Mentorship from Harvard Medical School/BWH.

He has published more than 45 research papers in international journals of repute. His developed mini microscope was recognized as one of the Royal Society of Chemistry’s Hot Paper. He has also been instrumental for innovations in fabricating 3D self-oxygenating artificial tissues for implants in volumetric tissue losses and has delivered numerous talks including one as a resource person for the innovations in frugal imagers studying in vitro disease models at the Ramon Cajal painting exhibition in MIT museum in 2018.

Dr. Hassan serves as an Associate Editor for Frontiers in Biomaterials Science. He served as Founding Associate Editor for MIT Science Policy Review (MIT, USA) in 2020. Additionally, he edits special issues for Polymers (MDPI), Frontiers in Pharmacology, etc. 

Dr. Hassan has founded 3 companies based in the UK, USA, and Kashmir.


Education
  • University of Zurich, Switzerland (Dr. Sc. Chemistry)
  • University of Pune, Maharashtra (M.Sc. Biotechnology)
  • University if Kashmir, Jammu and Kashmir (B.Sc. Chemistry, Biology, English)

Teaching
  • General Biology II (BIOL112)
  • General Genetics (BIOL211)
  • Internship (BIOL399)
  • Physiology (BIOL331)
  • Senior Research Project I (BIOL497)
  • Senior Research Project II (BIOL498)

Affiliated Research Institutes/Centers

Research
Research Interests
  • Bioengineering
  • 3D Bioprinting
  • Biomaterials
  • Rare and Genetic Diseases

Research Projects

Organ-on-a-chip systems and imaging technologies: Development of organ-on-a-chip platforms and their respective imaging modalities for miniaturized and portable volumetric imaging systems for organ-on-a-chip platforms.

Biomaterials for wound healing and therapeutic applications: Development of various biomaterial-based platforms that can be adapted to address various challenges in wound-healing biology and therapeutic approaches targeted at specific medical conditions. This research domain involves studies developing porous hydrogels that have the tendency to improve cellular invasion, thus showing better neovasculogenesis and enhanced healing abilities. Techniques involved include synthesis, sol-gel methods, sacrificial bioprinting, and encapsulation to develop therapeutic systems that have applications in wound biology and targeted therapy.

Microfabrication approaches for tissue engineering applications: Development of various microfabrication techniques that help to engineer the shape of cell-containing hydrogels or topographic cues of scaffolds for creating 2D and 3D functional tissue constructs. The techniques used range from 3D printing and sacrificial bioprinting to develop microfluidic systems for organ-on-a-chip devices.


Research Staff and Graduate Students:

Staff
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Students
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Additional Info

Personal Website: www.shabirhassan.com

Selected Publications: (*: Co-first; ^: Corresponding Author; Cover: Journal Cover Story)

1.     Prakash G, Shokr A, Willemen NGA, Bashir SM, Shin SR, Hassan S^, Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids. Adv Drug Deliv Rev. 114197, 2022.

2.     Willemen NGA*, Hassan S*, Gurian M, Jasso-Salazar MF, Fan K, Wang H, Becker M, Allijin IE, Bal-Ozturk A, Leijten J, Shin SR. Adv Health Mater. 2102697, 2022. (Cover).

3.     Li J, Yu X, Martinez EE, Zhu J, Wang T, Shi S, Shin SR, Hassan S^, Guo C^. Emerging biopolymer-based bioadhesives. Macromol. Biosci. 22(2)2100340, 2021.

4.     Duraj-Thatte AM, Manjula BA, Rutledge J, Xia J, Hassan S, Sourlis A, Rubio AG, Lesha A, Zenkl M, Kan A, Weitz DA, Zhang YS, Joshi NS. Programmable microbial ink for 3D printing of living materials produced from genetically engineered protein nanofibers. Nat. Comm. 12(1)1-8, 2021.

5.   Hassan S*^, Cecen B, Pena-Garcia R, Marciano FR, Miri AK, Fattahi A, Karavasili C, Sebastian S, Zaidi H, Lobo A. Enhancing vascularization in cell-laden hydrogels through oxygen releasing materials. J. Funct Biomater. 12(2)30, 2021.

6.   Farzin A*, Hassan S*, Teixeira LSM, Gurian M, Crispim JF, Manhas V, Carlier A, Bae H, Geris L, Noshadi I, Shin SR, Leijten Jeroen. Self-oxygenation of tissues orchestrates full-thickness vascularization of living implants. Adv. Funct. Mater. 31(42)2170308, 2021. (Cover)

7.   Li W, Wang M, Mille LS, Rbeldo Lara JA, Huerta V, Uribe Velazquez T, Cheng F, Hongbin Li, Gong J, A Murphy C, Lesha A, Hassan S, Woodfield TBF, Lim KS, Zhang YS: A Smartphone-Enabled Portable Digital Light Processing 3D Printer. Adv. Mater. 33:35,2170271, 2021. (Cover)

8.   Willemen NGA, Hassan S, Gurian M, Li J, Allijn IE, Shin SR, Leijten J. Oxygen releasing biomaterials: Current challenges and future applications. Trends Biotechol. 39(11)1144-1159, 2021. (Cover)

9.   EJ Bolívar-Monsalve, MM Álvarez, S Hosseini, MA Espinosa-Hernandez, Espinosa-Hernandez MA, Ceballos-González CF, Sanchez-Dominguez M, Shin SR, Cecen B, Hassan S, Di Maio E, de Santiago GT: Engineering bioactive synthetic polymers for biomedical applications: A review with emphasis on tissue engineering and controlled release. Mater. Adv. 2,4447-4478, 2021. (Cover)

10.  Ozturk AB, Cecen B, Adali, MA, Topkaya SN, Alarcin E, Yasayan G, Ethan YC, Bulkurcuoglu B, Akpek A, Avci H, Shin SR, Hassan S^. Tissue adhesives: From research to clinical translation. Nano Today, 36,101049, 2021.

Selected Awards and Honors

Best Student Award, UG studies in Kashmir University, India

University topper, undergrad, Kashmir University

Department of Biotechnology (India) fellowship for 2 years of masters

Endeavour Award (Australia) (not activated for LSZGS offer from Switzerland)

Life Sciences Zurich Graduate School (LSZGS) graduate Fellowship at ETH/UZH Zurich

Chemical and Molecular Sciences Zurich Fellowship at UZH Zurich

SNSF Early mobility postdoctoral fellowship from Switzerland

Chair at 4th Annual Workshop on Micro and Nanotechnologies in Medicine at HMS

Chair at 5th Annual Workshop on Micro and Nanotechnologies in Medicine at HMS

SNSF Advanced grant from Switzerland

Excellence in Mentorship Award from BWH, Harvard Medical School    

Invited Presentations (selected from >40 talks)

1. Invited talk, “Recent Advances in Bioengineering", Osmangazi University, Eskeshihir – Turkey, July. 2022

2. International Nanotechnology Seminar, “Organs in your pocket: confluence of biology, nanotechnology and bioengineering”, Northeastern University – USA, Oct. 2021

3. Panel discussion at Brunel University, London as a contributor to the book, “Together: An anthology from the Covid19 Pandemic”, discussing about the innovations lead on the scientific and technological front fighting covid in Kashmir and all over India, Nov. 2020.

4.   Lab based innovations: Shaping laboratories of the future, National Institute of Technology (NIT) – Srinagar India, 10th Aug 2020.

5.   Nanobiotech talks: “Frugal Innovations and Artificial Tissues”, Tec de Monterrey, Mexico, Sep 02, 2020.

6.   Seminar on Bioengineering Advances, KAUST, Saudi Arabia, Sep 15, 2020.

7.   Bioengineering Society Congress: Gebze Technical University, Turkey. Oct. 24, 2020.

8.   Oxygenating materials for tissue engineering, University of Kashmir, India, 2019

9.   Recent innovations in Biomedical Engineering, Tec De Monterrey, Mexico, 2019

10.   Talk as a resource person on frugal innovations in imaging for neuroscience on the occasion of Raman Cajal drawings at MIT Museum, 2018.

Vacancies

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