The Genes in Camel Kidneys Can Be Switched On and Off to Survive Dehydration

October 24, 2021

Researchers uncover how genes found in camel kidneys reveal a role for cholesterol in water conservation


Imagine a trek across the desert and you’ll likely picture a camel or two.


In the arid and semi-arid regions of North and East Africa, the Arabian Peninsula, and Iran, the Camelus dromedarius is the most important livestock animal and continues to provide basic needs to millions of people. Thought to have been domesticated for more than 3000 years, they have long been valued as pack animals, for milk, meat, and shelter, and even sport.


The Arabian camel is a symbol of the Arabian region, with its single hump storing up to 80 pounds of fat which it can break down into water and energy during its long expeditions for water and food.


To better understand how the Arabian camel manages to preserve water, Dr. Abdu Adem, Professor of Pharmacology at Khalifa University, supervised an investigation by a team of researchers from the University of Bristol and United Arab Emirates University. The investigation examined the genes in the kidneys of camels exposed to chronic dehydration to determine how Arabian camels can survive long periods of time in harsh conditions without access to water and what humanity could possibly learn from this. The results were published in Communications Biology.


Dr. Adem said. “Behavioral and physiological adaptations ensure that water is never wasted. Camels will only eat the leaves of plants, they avoid exposure to direct sunlight where possible, restrict reproduction to the cooler winter season, and drink very large amounts of water when available to compensate for any fluid deficiency from their desert wandering.”


Camels have been known to drink 30 gallons of water in just 13 minutes, but even here they have an evolutionary adaptation to avoid osmotic shock: they absorb the water very slowly. An intricate nasal passage prevents too much water loss when the camel breathes out, but more importantly, water evaporates from the surface of the nostrils to moisturize dry air when the camel breathes in, helping to cool the blood in the veins of the nose. Thanks to thin blood vessel walls, this cooler venous blood can help cool the blood in the arteries leading to the brain, meaning the camel’s brain is considerably lower in temperature than the body core. Even the red blood cells themselves have a special shape shown to be advantageous in withstanding dehydration. On top of all this, camels rarely sweat, even in the searing temperatures of the desert, all helping to conserve water for as long as possible.



“In the current context of climate change, there is renewed interest in the mechanisms that enable camels and camelids to survive in arid conditions,” Dr. Adem said. “We investigated the camel kidney to see how gene expression has been influenced by chronic dehydration and rapid rehydration. Our analysis suggests that genes with known roles in water conservation are affected by changes in cholesterol levels. Suppressing the production of cholesterol may help the kidney retain water.”


Camels produce highly concentrated urine, preserving as much water as possible. To produce such urine, the kidney must possess certain anatomical features. Previous research has shown that the kidney of a young camel differs in structure from that of an adult, suggesting that the differences may be related to a greater degree of water deprivation experienced by adult animals. This would suggest that chronic dehydration causes genes in the adult camel kidney to be expressed differently, allowing the kidney to better preserve water.


The research team noted that the amount of cholesterol in the kidney has a role in the water conservation process.


“We found remarkable changes in the amounts of specific genes and proteins in the kidney of the one-humped Arabian camel during severe dehydration and subsequent acute rehydration,” Dr. Adem said. “Our data suggests that the suppression of genes involved in cholesterol biosynthesis and the subsequent reduction in membrane cholesterol are a global response in the kidney to dehydration.”


Several ion channels and transporters are regulated by changes in the level of cholesterol in the cell. Dehydration and excessive heat cause electrolyte imbalances in the body, and the kidneys are one factor in keeping electrolyte levels balanced. If there is an increase of cholesterol in the membrane of the kidney, movement through the ion channels is blocked. When cholesterol levels are lowered, water and electrolytes can move across different parts of the kidney which helps reabsorb water and produce a highly concentrated urine. 


The researchers found that during the summer, the gene that regulates the production of a protein called aquaporin 2 is expressed more, presumably in preparation for the more challenging conditions of the season. Aquaporin 2 forms a channel in cell membranes to allow water molecules to pass through. During periods of dehydration, aquaporin 2 channels are inserted into the membranes of kidney cells which allows water to be reabsorbed into the bloodstream, making the urine more concentrated. The researchers found that when cholesterol was depleted, aquaporin 2 levels increased.



While this new knowledge contributes to our understanding of the immense evolutionary advantages the Arabian camel uses to survive in the desert, it could more importantly help humanity better adapt to advancing desertification amid climate change. Understanding the mechanisms of water control in dehydration could allow us to apply various principles to water conservation across a wide variety of disciplines.


Jade Sterling
Science Writer
24 October 2021