Two-dimensional (2D) materials have demonstrated many exceptional physical and chemical properties as well as broad applications in electronics, sensors, clean energy such as hydrogen production, ammonia and storage batteries etc. Usually, 2D materials such as Graphene, MXene and transition-metal dichalcogenide (TMDCs) can be produced through top-down approach by directly exfoliating through mechanical, liquid-phase and electrochemical methods. In this talk, our focus will be on wet chemistry approaches of developing 2D materials their nanoarchitectures and understanding their structure-property relationship through various advanced characterization. Applications of 2D materials and their analogues in sensors and energy conversion will be presented and also an outlook for the applications of computational approaches to 2D materials nanoarchitectures to understand influence of electronic, structural, and surface manipulation strategies will be provided.