In 2015, there were over 1 million people living with diabetes in the UAE, placing the country 13th worldwide for age-adjusted comparative prevalence. It is important to note that diabetes is a regional affliction in Saudi Arabia, Bahrain, Kuwait, and Qatar, all featuring in the top 15 countries in terms of prevalence worldwide. The first key area of our research is to extract metabolic, genomic, and socioeconomic markers associated with the early onset of type 2 diabetes (T2D) in UAE populations since no current studies have focused on the integrative system analysis to predict T2D in UAE populations. The anticipated outputs of this project are identification of the factors contributing to the high prevalence of T2D in the UAE. Secondly, we would like to develop an optimization strategy around prevention of these conditions. Thirdly, this model will contribute to understanding the etiology of T2D through probing the interactions between key genetic and environmental domains.