Professor and Chair, Department of Immunology and Physiology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, UAE 2019-present
Professor and Chair, Department of Physiological Sciences, Alfaisal University College of Medicine, Riyadh, Saudi Arabia 2008-2019.
Professor, Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA 2001-2008.
Associate Professor, Department of Obstetrics and Gynecology, The University of Illinois at Chicago, School of Medicine, Chicago, Illinois, USA 1996-2001.
Associate Professor, Assistant Professor, and Postdoctoral Fellow, Department of Physiology and Biophysics, Mayo Graduate School of Medicine, Rochester, Minnesota, USA 1986-1996.
Postdoctoral Fellow, Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, North Carolina, USA 1984-1986.
Signaling pathway of cardiac striatin during hypertension
Striatin (STRN) is a protein that is expressed in cardiac myocytes and plays an important role in maintaining normal contraction. It is possible that STRN does not function normally in the contraction of hypertrophied and/or dilated hearts. The Okamoto spontaneously hypertensive rat (SHR) is accepted as an animal model for human essential hypertension. Chronic hypertension in the SHR is often associated with cardiac remodeling and impaired myocardial contractility. We are investigating the possible changes in the expression of STRN in SHR hearts during the development and maintenance of hypertension in these rats.
My research interests focus broadly on the role of the kidney in hypertension and in pregnancy. Specifically, I have been studying the role of the kidney in the development and maintenance of hypertension and the renal adaptations to essential hypertension. In addition, I have studied the mechanisms that are responsible for the renal hemodynamic, excretory, as well as cardiovascular adaptations during normal pregnancy. Another area of research interest that we have developed in my lab is to study renal and cardiovascular functions in diabetic pregnancy, and development and maintenance of hypertension in a diet-induced obesity rat model. Recently, we have been studying the signaling pathway of cardiac striatin during hypertension and diabetes.
Students or trainees who are interested in our research or in any of the ongoing projects are invited to send their CV/request to the PI.