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Dr. Abdulrahim Sajini completed his masters degree in Stem Cell Biology from the University of Minnesota, USA and PhD in Stem Cell Biology and RNA Post-transcription modifications from the University of Cambridge, UK. In Minnesota he was involved in studying pluripotency in embryonic / induced pluripotent stem cells. Later, in Cambridge he worked with Dr. Michaela Frye investigating how RNA post-transcription modifications on non-coding RNAs modulate adult stem cell self-renewal. Subsequently, he completed his post-doc at the University of Cambridge researching RNA methylation dependent binding proteins and non-canonical microRNA pathways. He has published papers in tope journals such as Developmental Biology, Cell press and Nature.
Dr. Abdulrahim also completed his entrepreneurship training at the Judge Business School in the University of Cambridge as part of the Accelerate Cambridge program in 2015.
His research interests are focused on stem cells, RNA post-transcription modifications, islet transplants, Diabetes, and non-coding RNAs.
Molecular and cellular physiology I
Molecular and cellular physiology II
Research interests are focused on stem cells, RNA post-transcription modifications, islet transplants, Diabetes, and non-coding RNAs.
Abdulrahim A. Sajini, Gracjan Michlewski, Michaela Frye. Writing and reading of 5-methylcytosine orchestrates non-coding Vault RNA processing into small regulatory RNAs to coordinate epidermal differentiation. Nat. Commun. (2018) In review.
Abdulrahim A.Sajini, Michaela Frye (2018) RNA modifications in the control of stem cell activity and epidermal differentiation. In Epigenetic Regulation of Skin Development and Regeneration. Vladimir A. Botchkarev, Sarah E .Miller (ed), 1st edn: SPRINGER.
Sandra Blanco1, Roberto Bandiera1, Martyna Popis1, Shobbir Hussain2, Jelena Aleksic1, AbdulrahimSajini1,Hinal Tanna3, Nikoletta Gkatza1, Sabine Dietmann1, Michaela Frye1.Stem cell function and stress response are controlled by protein synthesis. Nature. 2016 Jun 15;534 (7607):335-40. PMID:27306184
Shobbir Hussain, Abdulrahim A. Sajini, Sandra Blanco, Sabine Dietmann, Patrick Lombard, Yoichi Sugimoto, Maike Paramor, Joseph G. Gleeson, Duncan T. Odom, Jernej Ule, Michaela Frye. NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs. CellReports,(4) 255–261, July 25,2013.
Greder, L.V., Gupta, S., Li,S., Abedin, Md. J., Sajini, A., Segal, Y., Slack, J.M.W. and Dutton, J. R. (2012), Brief Report: Analysis of Endogenous Oct4 activation during Induced pluripotent stem cell Reprogramming Using an Inducible Oct4 Lineage Label. STEM CELLS, 30: 2596–2601.
Abdulrahim A. Sajini, Lucas V. Greder, James R. Dutton, Jonathan M.W. Slack, Loss of Oct4 expression during the development of murine embryoid bodies, Developmental Biology, Volume 371, Issue2,15 November 2012, Pages170-179.